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- W2373281623 abstract "Objective To evaluate the epidemiological status of HIV-1 infection in blood donors from Guangzhou. Methods Totally 581 656 samples from blood donors were collected between Jan 1st,2010 to Dec 31 th 2011. AntiHIV of these samples were parallelly tested by two ELISA kits from different manufacturers. Samples with both positive ELISA results were confirmed by Western Blot( WB) in the Centers for Disease Control and Prevention in Guangzhou. Based on the results of WB,RNA of HIV from positive samples was isolated and gag gene of HIV virus was amplified and sequenced by RT-PCR method to obtain the genotypes. The related statistic analysis was conducted using SPSS 16. 0 software. Results Anti-HIV was both positive in 133 out of 581,656 donors by using two different ELISA kits.( 133 /581,656,0. 023%). Among the 133 samples with positive ELISA results,120 cases were positive for WB( 120 /581,656,0. 021%). Six sub-genotype of HIV-1 were identified in these 120 donors. CRF01-AE recombinant genotype were detected in 51 donors,CRF07-BC were detected in 32 donors,CRF08-BC were detected in 15 donors,O1B were detected in 16 donors,and B'were detected in 6 donors. The statistical analysis of anti-HIV distribution showed that heterosexual transmission is higher than the other routes of transmission. Male group is higher than female group. Ecdemic group is higher than local group. And first-time donors is higher than fixed donors. Donors with junior high school degree or below have a higher risk than other groups,and donors age of 26-35 years have a higher risk than other age groups. Conclusion The majority of donors with HIV-1 infection in Guangzhou are young males from other places and the main way of transmission is across sexual transmition." @default.
- W2373281623 created "2016-06-24" @default.
- W2373281623 creator A5066829203 @default.
- W2373281623 date "2014-01-01" @default.
- W2373281623 modified "2023-09-23" @default.
- W2373281623 title "Epidemiological analysis of HIV-1 Infection in Guangzhou blood donors from 2010 to 2011" @default.
- W2373281623 hasPublicationYear "2014" @default.
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