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- W2373287461 abstract "Aim: To detect B19-DNA on bone marrow samples among children with malignant tumors by using nestedpolymerase chain reaction (Nested-PCR)technique that wasthe states of parvovirus B19 infection in children with malignant tumors. Methods: We conducted a case-control studyto investigate the infection of B19 DNA on bone marrowsamples of 71 children with malignant tumors including 59cases of acute and chronic leukemia, 12 cases of malignantlymphoma in our hospital and 26 cases of health childrenwith nested-PCR technique. Results:①The positive rate ofB19-DNA on bone marrow samples was 33. 8% (24/71)during chemotherapy, significantly higher than in controlgroup (P0. 01).②Comparing leukemia with lymphomain 24 B19-DNA positive patients,there was no statistical difference (P0. 05). There were 3 patients negative for B19-DNA before chemotherapy, but positive during chemotherapy. ③B19 infection was higher in acute lymphoblasticleukemia during chemotherapy, with infection rate of 41.2%. Complete remission (CR) rate of leukemia was slightlyincreased. Conclusion: These results showed that childrenwith malignant tumors who received chemotherapy and wereimmunosuppressed easily underwent parvovirus B19 infection,inducing bone marrow failure and(or) chronic anemia." @default.
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- W2373287461 title "Detection of human parvovirus B19 on bone marrow samples among children with malignant tumors" @default.
- W2373287461 hasPublicationYear "1998" @default.
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