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- W2373290037 abstract "ne of the major problems in cancer chemotherapy is the phenomenon of multidrug resistance (MDR). Circumvention of MDR plays an important role in improving the remission rate of cancer patients. The chinese herb decoctionR1 was consist of some tractional chinese herbs, such as CHUAN XIONG, JI XUE TENG ect. We had confirmedthat R1 could revers the MDR phenotype of drug--resistant human breast cancer cell line in vitro. In this study, we investigated the possible mechanism of R1 on circumvention of MDR in this drug--resistant cell line.Immunocytochemical assay and western blot verified that p-glycoprotein (PGP) was overexpressed in MCF7adrcells, while no PGP signal was found in wild type MCF7 cells. By treatment with R1 (1: 60, 1: 90) for two or threehours, the PGP expression in MCF7adr was decressed. The effect of R1 on PGP expression was time or dose-dependence.Northern blot results showed that the expression of mdr1 mRNA in MCF7adr cells was very high, while the expression ofit in MCF7 cells was undetectable. The expression of MDR1 mRNA was decreased in the presence of R1 (1: 60, 1:90 )for two or three hours. The longer the time. the more effect the R1. No obvious difference was found when MCF7adr,cells were treated with 1: 60 R1 or 1: 90 R1, although both of them could reduce the mdr1 mRNA expression.The results indicated that one of the mechanism of MDR was decreasing the expression of PGP at the level oftranscription and translation in vitro, and thus increased the accumulation of antitumor drugs in MCF7adr cells and theircytotoxity." @default.
- W2373290037 created "2016-06-24" @default.
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- W2373290037 date "1996-01-01" @default.
- W2373290037 modified "2023-09-25" @default.
- W2373290037 title "Effect of Chinese Herb Decoction R1 on The Expression of p--glycoproteinof Adriamycin--resistant Human Breast Cancer Cell Line" @default.
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