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- W2373296748 abstract "Objective: To observe the inl uence of cake-separated moxibustion on the expression of 5-HT and central c-fos in rats with functional gastrointestinal disorders(FGIDs), and to investigate the possible mechanism and therapeutic effect of cake-separated moxibustion in rats with FGIDs of liver-depression and spleen-dei ciency syndrome. Methods: 48 SD rats were divided into 4 groups according to the table of random number: a blank group(A), a model group(B), cake-separated moxibustion group(C), Xiaoyao Powder group(D), 12 in each group. Rats in group A were normal feeding without any treatment. The rest three groups were made with complex modeling methods for 21 days(chronic restraint stress + excessive fatigue + irregular food + tail clamp + shake). Group B was bounded for 30 min and given normal saline by gavage, and the gavage volume was 1mL/100g(the same below). Group C was treated with cake-separated moxibustion for 30 min, and given normal saline by gavage. Group D was bounded for 30 min, and given Xiaoyao Powder by gavage for 14 days. After the experiment i nished, the expression of 5-HT in colon tissues was detected by high performance liquid chromatography(HPLC), and the expression of c-fos in hippocampus and amygdala were detected by l uorescence quantitative PCR. Results: Compared with the blank group, the expression of 5-HT in colon tissues of rats in the model group was statistically signfiicantly dif erent(P0.01). Compared with the model group, the expression of 5-HT in colon tissue of rats decreased in Xiaoyao Powder group and cake-separated moxibustion group, and the dif erences were statistically signfiicant(P0.05, P0.01). Compared with Xiaoyao Powder group, the dif erence in cake-separated moxibustion group was statistically significance(P0.05). Compared with the blank group, the expression of c-fos in hippocampus and amygdala was statistically signfiicant in the model group(P0.05). Compared with the model group, there was statistically dif erence in cake-separated moxibustion group and Xiaoyao Powder group(P0.05). There was statistically dif erence between cake-separated moxibustion group and Xiaoyao Powder group(P0.05). Conclusion: Cake-separated moxibustion can downregulate the expression of 5-HT in colon tissues to improve gastrointestinal absorption and paresthesia. The abnormal expression of the colon 5-HT, hippocampus and amygdala c-fos prompted the pathogenesis of the FGIDs, it not only related with endocrineimmune system, meanwhile the nervous system is involved in the occurrence of this disease, so it suggests that the brain-gut axis way may be the key to treat FGIDs with cake-separated moxibustion." @default.
- W2373296748 created "2016-06-24" @default.
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- W2373296748 date "2014-01-01" @default.
- W2373296748 modified "2023-09-27" @default.
- W2373296748 title "Effects of cake-separated moxibustion on the expression of 5-HT and central c-fos in rats with functional gastrointestinal disorders(liver-depression and spleen-deficiency syndrome)" @default.
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