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- W2373297567 abstract "Transforming growth factors-β(TGF-β)are a class of cytokines with many kinds of biologic activity, which regulate cell proliferation,differentiation,development and apoptosis.According to the studies in recent years,TGF-βacts upon tumor through a broad and complex spectrum of interdependent interactions.In terms of sites,TGF-βsignaling pathways show a significant role in tumor suppression and tumor promotion by tumor-cell-autonomous effects,and also promote or suppress carcinoma progression and metastasis by affecting the tumor microenvironment,such as fibroblasts, immune cells and the extracellular matrix.In terms of stages,prior to initiation and early during progression TGF-βacts as a tumor suppressor restraining cell proliferation,initiating cell differentiation and inducing cell apoptosis,however at later stages in tumor progression it often acts in many ways to promote tumor migration and metastasis.The complex nature of TGF-βsignaling presents a unique challenge and an opportunity to discover the mechanism of tumor and to develop therapeutic intervention strategies for targeting cancer." @default.
- W2373297567 created "2016-06-24" @default.
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- W2373297567 date "2008-01-01" @default.
- W2373297567 modified "2023-09-25" @default.
- W2373297567 title "TGF-β Signaling Pathway's Function in Tumor Initiation, Progression and Metastasis" @default.
- W2373297567 hasPublicationYear "2008" @default.
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