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- W2373313187 abstract "The JAK/STAT pathway that contributes to signal transduction by cytokines,growth factors and hormones is universally activated in leukemias.Leukemogenesis is frequently associated with the aberrant expression of activated fusion tyrosine kinases or activated protein tyrosine kinases carrying mutations.The activated kinase enzymes result in continuative activation of JAK/STAT signaling pathway.Furthermore,some virus infections are associated with dysregulation of JAK/STAT pathway.The dysregulation of JAK/STAT pathway contributes to cellular malignant transformation and leukemogenesis.A better understanding of mechanisms of the dysregulation of JAK/STAT signaling pathway may serve as a basis for designing novel therapeutic strategies that target these pathway in leukemia cells." @default.
- W2373313187 created "2016-06-24" @default.
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- W2373313187 date "2006-01-01" @default.
- W2373313187 modified "2023-09-27" @default.
- W2373313187 title "Constitutive activation of JAK/STAT signaling pathway in leukemogenesis" @default.
- W2373313187 hasPublicationYear "2006" @default.
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