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- W2373315038 abstract "Objective To investigated the therapeutic effects and mechanisms of hedyotis diffusa(HD) against multiple myeloma cell line RPMI 8226 cells,in order to give the theory for clinical application.Methods MTT assay was used to examine the effects of HD on the proliferation of multiple myelomacell lines RPMI 8226.AV/PI flow cytometry technique was used to detect cell apoptosis.Hoechst staining was used to observe the morphological changes.Results The MTT assay showed that HD significantly inhibited the proliferation of RPMI 8226 cells from the doses from 1mg/ml to 4mg/ml,the best inhibition rate reached to 92.68%.It showed that HD inhibited the proliferation of RPMI 8226 cell lines in a dose-and-time-dependent manner.RPMI 8226 was incubated with different concentrations of HD(1mg/mL,2mg/mL,3mg/mL) for 24h occurred 22.52%,62.31%,69.94% apoptotic cells,which was more than that of untreated group(8.93%).After treated with HD,apoptotic body appeared in RPMI 8226 cells nucleus and in a dose-dependent manner.Conclusion HD can significantly inhibit the proliferation of RPMI 8226 cells from the concentration of 1.0 mg/mL to 4.0 mg/mL,its mechanism may be inducing cell apoptosis.The results give the experimental theory for the clinical application of HD." @default.
- W2373315038 created "2016-06-24" @default.
- W2373315038 creator A5054596819 @default.
- W2373315038 date "2012-01-01" @default.
- W2373315038 modified "2023-09-26" @default.
- W2373315038 title "Effect of Hedyotis Diffusa on RPMI 8226 Cells Apoptosis" @default.
- W2373315038 hasPublicationYear "2012" @default.
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