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- W2373317963 abstract "Objective To investigate IGF/FGF interactions in neuronal cells, and demonstrate whether SOCS genes are regulated in IGF or/and FGF treated neuroblastoma cells. Methods Neuroblastoma cells(SK-N-MC) were employed as in vitro models for neuronal cells, and cells were treated with IGF-1, FGF-2 or combination of IGF-1 and FGF-2. We observed the cells for growth arrest, morphological differences at 24, 48 and 72 h after being treated. SOCS1, 2, 3 mRNA expression were detected by RT-PCR of the 48 h-cells. Results In the cells treated with IGF-1, cell number increased, no morphological differences were observed, and SOCS2 mRNA expression was down-regulated; The cell proliferation was inhibited significantly in the FGF-2 treated cells, they showed prominent differentiation, and SOCS2mRNA expression was up regulated. Those simultaneously treated with IGF-1 and FGF-2 showed similar phenotype to FGF-2 treated alone, but the changes were more pronounced. Conclusion FGF-2 over-rides IGF-1 induced proliferation and cell survival in human neuroblastoma cell, and up-regulation of SOCS2mRNA may be one of its mechanisms." @default.
- W2373317963 created "2016-06-24" @default.
- W2373317963 creator A5060767771 @default.
- W2373317963 date "2006-01-01" @default.
- W2373317963 modified "2023-09-23" @default.
- W2373317963 title "Influence of IGF-1 and FGF-2 on differentiation of neuroblastoma cells and relationship with SOCS" @default.
- W2373317963 hasPublicationYear "2006" @default.
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