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- W2373366515 abstract "OBJECTIVE: To investigate the role of Nrf2 in thyroid cancer cell apoptosis induced by proteasome inhibitor.METHODS: A panel of anaplastic thyroid cancer cells(FRO,KTC1,KTC2,KTC3,8305C and 8505C) were treated with vehicle or bortezomib;the expression of Nrf2 in the panel of thyroid cancer cells were investigated using Western blot analysis;the nuclear localization of Nrf2 were observed using confocal microscopy;apoptotic cells were analyzed using flow cytometry.RESULTS: Compared with FRO and KTC2 cells,8305C and 8505C cells,which were insensitive to apotosis induced by bortezomid,demonstrated higher basal Nrf2 expression,the apoptotic rates in these four cell lines were(51.98±3.01)%,(46.92±2.72)%,(17.33±4.18)% and(7.97±1.01)%,respectively;bortezomid induced nuclear translocation of Nrf2 in 8505C and 8305C cells.CONCLUSION: Nrf2 can inhibit thyroid cancer cell apoptosis induced by proteasome inhibitor,and nuclear translocation of Nrf2 mediated by proteasome inhibitor may be responsible for its antiapoptotic effects." @default.
- W2373366515 created "2016-06-24" @default.
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- W2373366515 date "2012-01-01" @default.
- W2373366515 modified "2023-09-26" @default.
- W2373366515 title "Role of Nrf2 in apoptosis of thyroid cancer cells mediated by proteasome inhibitor" @default.
- W2373366515 hasPublicationYear "2012" @default.
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