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- W2373375369 abstract "Objective To analyze the outcomes of azithromycin-based comprehensive treatment for 51 patients with diffuse panbronchiolitis(DPB).Methods Totally 51 DPB patients(30 males and 21 females,mean age 54 years),who were treated with azithromycin in our hospital from Jul.1,2001 to Apr.30,2007,were included in the present study and were followed up to Jan.28,2008.The patients received comprehensive treatment using macrolides like Azithromycin,together with azithromycin,glucorcoticord,antibiotics,oxygen therapy,and supportive therapy,etc.The clinical,radiological characteristics,arterial gas analysis,lung function,microbiological findings,response to the therapy,and prognosis were observed before and after treatment.Results All patients presented with chronic cough and 50(98.0%) with copious purulent sputum production;49(96.1%) had dyspnea on exertion;33(64.7%) had wheezes;and 49(96.1%) had end inspiratory crackles in their chest as initial presentation.Twenty-five patients(49.0%) had emphysema;49(96.1%) had chronic sinusitis;14(27.5%) had smoking history;26(51.0%) had bronchoectasis;5(9.8%) had cor pulmonale;4(7.8%)had asthma at same time;and 2(a sister and an younger brother)came from the same family.Only 9 patients(17.6%) had elevated cold haemagglutinin titers and 5(9.8%) had lung biopsy specimens.Three of 12 subjects(25.0%) had positive expression of human leukocyte antigen-B54(HLA-B54).Seventeen(33.3%)had positive sputum Pseudomonas aeruginosa.Thirty(58.8%) were misdiagnosed as having bronchoectasis and 23(45.1%) were misdiagnosed as having chronic bronchitis initially.Fourteen(27.5%)patients recovered entirely after therapy,but 2 of them relapsed after stopping treatment,and improved when given therapy again.Thirty-six cases were improved,but 2 of them died from other diseases during following up.The 5-year-survival rate was 95.6%.Conclusion DPB patients likely exist among patients with bronchoectasis,chronic bronchitis and other pulmonary diseases.Azithromycin-based comprehensive treatment has a satisfactory outcome in treatment of DPB.(Shanghai Med J,2009,32: 854-859)" @default.
- W2373375369 created "2016-06-24" @default.
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- W2373375369 date "2009-01-01" @default.
- W2373375369 modified "2023-09-25" @default.
- W2373375369 title "Azithromycin-based comprehensive treatment of diffuse panbronchiolitis:an outcome analysis of 51 cases" @default.
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