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- W2373396246 abstract "Objective:To study the effects of the gene expression of nm23 and VEGF on onco-genesis and progression of ovarian cancer. Methods:The expression of nm23 gene protein and VEGF were examined immunohistochemically in 58 cases of ovarian serous cystadenocarcinoma, 10 cases of borderline serous cystadenomas and 13 cases of serous cystadenocarcinoma. The relationships between the results and clinicopathological features were studied.Results:(1) The expressions of nm23 in benign and malignant tumors were different significantly (P0.05).The expression of nm23 in cystadenocarcinoma was associated with histologic grade, clinical stage,lymphonode metastasis and ascites (P0.01, P0.01, P0.01, P0.05). (2) The expression rates of VEGF in borderline and malignant tumors were higher than that in benign tumors, and differences between them were significant (P0.01).The expression of VEGF in cancers was associated with lymphonode metastasis and ascites(P0.01, P0.05). (3) nm23 and VEGF showed co-expression in some of the carcinoma. Conclusion: The experiment suggests that nm23 and VEGF play roles in oncogenesis and progression of ovarian cystadenocarcinoma, but repectively to different extent. Detection of nm23 and VEGF protein has positive effect on malignancy determination, prognosis and treatment of ovarian tumors." @default.
- W2373396246 created "2016-06-24" @default.
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- W2373396246 date "2001-01-01" @default.
- W2373396246 modified "2023-09-25" @default.
- W2373396246 title "STUDY ON EXPRESSION AND CLINICAL SIGNIFICANCE OF nm23 AND VEGF IN OVARIAN SEROUS ADENOCYSTIC NEOPLASMS" @default.
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