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- W2373396854 abstract "AIM To study the apoptotic pathway of oridonin-induced A375-S2 cell apoptosis. METHODS Morphological observation, agarose gel electrophoresis, caspase inhibitors and Western Blot analysis were applied. RESULTS Oridonin had significant apoptotic effect on A375-S2 cells in a dose-and a time-dependent manners. The marked morphological changes including condensed chromatin, nuclear fragmentation and apoptotic bodies and DNA ladder in agarose gel was observed. The activity of caspase-3 was increased about 6 times of control value after treatment with oridonin. Furthermore, treatment of A375-S2 cells with oridonin for 12 h increased the protein expression ratio of Bax/Bcl-xL, and PARP, a substrate of caspase-3, was activated at 12 h. CONCLUSION Oridonin induces A375-S2 cell apoptosis via mitochondria-regulated caspase pathway activation." @default.
- W2373396854 created "2016-06-24" @default.
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- W2373396854 date "2004-01-01" @default.
- W2373396854 modified "2023-09-26" @default.
- W2373396854 title "Oridonin induced A375-S2 cell apoptosis through caspase-3 pathway after altered expression of Bax/Bcl-xL" @default.
- W2373396854 hasPublicationYear "2004" @default.
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