Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373404890> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2373404890 endingPage "7" @default.
- W2373404890 startingPage "123" @default.
- W2373404890 abstract "To investigate the dynamic expression and role of SENP1 (SUMO-specific proteases-1) in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension (HPH).Forty adult male Wistar rats were randomly divided into 5 groups (n = 8), and exposed to normoxia (Control group) or exposed to hypoxia for 3, 7, 14 or 21 d, respectively. The HPH models were established by normobaric intermittent hypoxia. Mean pulmonary arterial pressure (mPAP), right ventricle hypertrophy index (RVHI), and vessel morphometry were measured. Reverse transcriptase-polymerase chain reaction(RT-PCR) and in situ hybridization were used to determine the mRNA expression of SENP1. Immunohistochemistry and Western blot were used to determine the protein expression of SENP1.The hypoxic rats developed pulmonary vascular remodeling in pulmonary arterioles after 7 d of hypoxia exposure. Pulmonary vascular remodeling in pulmonary arterioles significantly increased after 14 d of hypoxia. The level of mPAP in hypoxic rats increased significantly after 7 d of hypoxia, reached its peak after 14 d of hypoxic exposure. RVHI was markedly increased after 14 d of hypoxia. In situ hybridization and immunohistochemical analysis showed that SENP1 mRNA and protein were positively stained in control. SENP1 mRNA expression had little changes after exposure to hypoxia compared with the control, however, SENP1 protein expression was declined gradually after 7 d of hypoxia. The results of RT-PCR and Western blot showed that the same dynamic expression of SENP1 mRNA and protein in lung tissues of rats. Linear correlation analysis showed that SENP1 protein were negatively correlated with mPAP, pulmonary vascular remodeling index and RVHI.Under chronic hypoxia, SENP1 protein can be degradated. The dynamic expression of SENP1 protein may play a role in implicating in the development of HPH." @default.
- W2373404890 created "2016-06-24" @default.
- W2373404890 creator A5010095998 @default.
- W2373404890 creator A5029165148 @default.
- W2373404890 creator A5031914883 @default.
- W2373404890 creator A5044462846 @default.
- W2373404890 creator A5083255781 @default.
- W2373404890 date "2012-03-01" @default.
- W2373404890 modified "2023-09-26" @default.
- W2373404890 title "[The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension]." @default.
- W2373404890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22737911" @default.
- W2373404890 hasPublicationYear "2012" @default.
- W2373404890 type Work @default.
- W2373404890 sameAs 2373404890 @default.
- W2373404890 citedByCount "3" @default.
- W2373404890 countsByYear W23734048902012 @default.
- W2373404890 countsByYear W23734048902014 @default.
- W2373404890 countsByYear W23734048902022 @default.
- W2373404890 crossrefType "journal-article" @default.
- W2373404890 hasAuthorship W2373404890A5010095998 @default.
- W2373404890 hasAuthorship W2373404890A5029165148 @default.
- W2373404890 hasAuthorship W2373404890A5031914883 @default.
- W2373404890 hasAuthorship W2373404890A5044462846 @default.
- W2373404890 hasAuthorship W2373404890A5083255781 @default.
- W2373404890 hasConcept C104317684 @default.
- W2373404890 hasConcept C105580179 @default.
- W2373404890 hasConcept C126322002 @default.
- W2373404890 hasConcept C134018914 @default.
- W2373404890 hasConcept C142724271 @default.
- W2373404890 hasConcept C178790620 @default.
- W2373404890 hasConcept C185592680 @default.
- W2373404890 hasConcept C204232928 @default.
- W2373404890 hasConcept C2776415932 @default.
- W2373404890 hasConcept C2777714996 @default.
- W2373404890 hasConcept C2778921608 @default.
- W2373404890 hasConcept C2779376020 @default.
- W2373404890 hasConcept C2780930700 @default.
- W2373404890 hasConcept C540031477 @default.
- W2373404890 hasConcept C55493867 @default.
- W2373404890 hasConcept C71924100 @default.
- W2373404890 hasConcept C7836513 @default.
- W2373404890 hasConcept C81439078 @default.
- W2373404890 hasConcept C86803240 @default.
- W2373404890 hasConceptScore W2373404890C104317684 @default.
- W2373404890 hasConceptScore W2373404890C105580179 @default.
- W2373404890 hasConceptScore W2373404890C126322002 @default.
- W2373404890 hasConceptScore W2373404890C134018914 @default.
- W2373404890 hasConceptScore W2373404890C142724271 @default.
- W2373404890 hasConceptScore W2373404890C178790620 @default.
- W2373404890 hasConceptScore W2373404890C185592680 @default.
- W2373404890 hasConceptScore W2373404890C204232928 @default.
- W2373404890 hasConceptScore W2373404890C2776415932 @default.
- W2373404890 hasConceptScore W2373404890C2777714996 @default.
- W2373404890 hasConceptScore W2373404890C2778921608 @default.
- W2373404890 hasConceptScore W2373404890C2779376020 @default.
- W2373404890 hasConceptScore W2373404890C2780930700 @default.
- W2373404890 hasConceptScore W2373404890C540031477 @default.
- W2373404890 hasConceptScore W2373404890C55493867 @default.
- W2373404890 hasConceptScore W2373404890C71924100 @default.
- W2373404890 hasConceptScore W2373404890C7836513 @default.
- W2373404890 hasConceptScore W2373404890C81439078 @default.
- W2373404890 hasConceptScore W2373404890C86803240 @default.
- W2373404890 hasIssue "2" @default.
- W2373404890 hasLocation W23734048901 @default.
- W2373404890 hasOpenAccess W2373404890 @default.
- W2373404890 hasPrimaryLocation W23734048901 @default.
- W2373404890 hasRelatedWork W2047059589 @default.
- W2373404890 hasRelatedWork W2355100107 @default.
- W2373404890 hasRelatedWork W2360437166 @default.
- W2373404890 hasRelatedWork W2363109175 @default.
- W2373404890 hasRelatedWork W2374601116 @default.
- W2373404890 hasRelatedWork W2387125662 @default.
- W2373404890 hasRelatedWork W2392371029 @default.
- W2373404890 hasRelatedWork W2409288104 @default.
- W2373404890 hasRelatedWork W2429411256 @default.
- W2373404890 hasRelatedWork W2473200681 @default.
- W2373404890 hasVolume "28" @default.
- W2373404890 isParatext "false" @default.
- W2373404890 isRetracted "false" @default.
- W2373404890 magId "2373404890" @default.
- W2373404890 workType "article" @default.