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- W2373407029 abstract "Objective To understand effects of selenium (Se) on the electrocardiogram (ECG) and action potential (AP) in rats.Methods Wistar rats were given intraabdominal injection of Se (0.02mg.kg 1 ) once daily for 2 weeks and every other day for 7 weeks.After injection of Se the changes of Q_T interval and AP in healthy rats and rats with cardiomyopathy of adriamycin (ADM) were observed with ECG and the technique of intracelluar glass microelectrode recording.Results The action potential duration (APD 50 ) of ventricular papillary muscle was prolonged (P0.05) but Q-T interval of ECG was not changed in healthy rats after injection of Se.Both Q-T interval and APD(APD 50 ,APD 90 ) were all prolonged (P0.05~0.01) in rats with cardiomyopathy of ADM after injection of Se.Se had no effects of the heart rate,restiong potential (RP),amplitude of action potential (APA) and the maximum depolarization rate of AP (Vmax).Conclusions Se could prolong APD 50 but could not affect clearly Q-T interval in healthy rats.Se could not reverse changes of APD(APD 50 ,APD 90 ) and Q-T interval in rats with cardiomyopathy of ADM.The results are very significant for provention and treatment of cardiomyopathy. [" @default.
- W2373407029 created "2016-06-24" @default.
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- W2373407029 date "1999-01-01" @default.
- W2373407029 modified "2023-09-25" @default.
- W2373407029 title "Effects of selenium on electrocardiogram and action potential in rats" @default.
- W2373407029 hasPublicationYear "1999" @default.
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