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- W2373412998 abstract "OBJECTIVE To identify the carbapenemase genotypes in imipenem-resistant Acinetobacter baumannii strains isolated from the hospital so as to prouide basis for the clinical preuention of infeetions and for the use of antibiotics.METHODS A total of 65 strains of imipenem-resistant A.baumannii were collected from Sep 2008 to Dec 2010.The antibiotic susceptibility testings were carried out by K-B disc diffusion,agar dilution method was employed to determine the MIC to polymyxin B;carbapenemases were screened by modified Hodge test,the phenotype of metalloenzyme was detected with EDTA disk synergy test;the encoding genes including OXA-23,OXA-24,OXA-51,OXA-58,IMP,and VIM were determined by PCR.RESULTS The drug susceptibility rate of the 65 strains of A.baumannii to minocycline was 19.0%,the susceptibility rates to other 11 antibiotics were less than 10.0%;the MIC to polymyxin B was lower than 2μg/ml;the positive rate of Hodge test was 52.3%,all strains carrying OXA-51 were positive,the positive rate of OXA-23 gene was 93.85%,all strains carrying OXA-24 or OXA-58 were negative,and no metalloenzyme genes were detected.CONCLUSION OXA-23 gene is the most popular carbapenemase encoding gene in imipenem-resistant A.baumannii." @default.
- W2373412998 created "2016-06-24" @default.
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- W2373412998 date "2012-01-01" @default.
- W2373412998 modified "2023-09-27" @default.
- W2373412998 title "Study on carbapenemases in imipenem-resistant Acinetobacter baumanniiisolates" @default.
- W2373412998 hasPublicationYear "2012" @default.
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