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- W2373422025 abstract "Objective: To investigate the effects of injury on primary cultured skin cells induced by sodium arsenite. Methods: Count cell number, MTT reduction assay,transmission electron microscope were performed in primary cultured skin cells, sodium arsenite was used as tester. Results: With different concentrations of 0.5～8 μmol/L sodium arsenite, the skin fibroblasts were markedly stimulated and showed a dose effect relationship. Sodium arsenite at lower concentrations (0.8 μmol/L?1.6 μmol/L) induced mainly the degree of proliferation of epidermic cell, while inhibiting cell growth over 3.2 μmol/L. At concentration of 10 μmol/L, however, sodium arsenite induced injury of skin fibroblasts. Conclusion: The proliferation of skin cell may play a critical role in the development of skin injury caused by inorganic arsenic, the mechanism of DNA injury in primary cultured human skin cells needs further study." @default.
- W2373422025 created "2016-06-24" @default.
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- W2373422025 date "2003-01-01" @default.
- W2373422025 modified "2023-09-23" @default.
- W2373422025 title "Effects of proliferation on primary cultured human skin cells induced by sodium arsenite" @default.
- W2373422025 hasPublicationYear "2003" @default.
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