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- W2373428291 abstract "Objective To investigate the regulatory effects of multiple intracellular on growth hormone (GH) secretion by human pituitary somatotrophinomas.Methods Using cell culture in vitro and PCR direct sequencing,the regulatory effects of intracellular second messengers cAMP, inositol phosphates and Ca 2+ on GH secretion were observed. The expression of gsp oncogenes was also studied.Results As usually reported, gsp oncogenes expressed in 6 of 18 tumors (33%). The effect of GHRP 6 and GHRH on cAMP production was observed in 11 tumors. GHRP 6 exerted no effect on cAMP production by gsp negative tumors, but stronger effect by 2 gsp positive tumors. Moreover, GHRP 6 potentiated the stimulation of cAMP production induced by GHRH in tumors without gsp oncogenes. GHRP 6 stimulated strongly GH secretion and PI turnover. The effects of GH secretion were reduced or abolished by inhibitors of protein kinase C (phloretin) and calmodulin (W7).Conclusion Intracellular multiple might involve in the regulation of GH secretion." @default.
- W2373428291 created "2016-06-24" @default.
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- W2373428291 date "2001-01-01" @default.
- W2373428291 modified "2023-09-22" @default.
- W2373428291 title "The regulation of multiple intracellular second messengers on growth hormone secretion by human pituitary somatotrophinomas" @default.
- W2373428291 hasPublicationYear "2001" @default.
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