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- W2373446181 abstract "Objective This study was designed to examine the relationship between polymorphism at the Apo E gene and the risk of coronary artery disease(CAD).Furthermore,the association of the polymorphism with the classical risk factors was analyzed.Methods103patients with angiographically verified CAD were evaluated.Data referring to hypertension,diabetes and tobacco consumption were recorded.The levels of total cholesterol,HDL cholesterol,Apo A1and B and triglycerides were determined.DNA was obtained from the103patients and from54controls.In order to determine the Apo E polymorphism,DNA was PCR amplified and digested with HhaI.The ge-netic polymorphism of Apo E is due to three common alleles,e2,e3,e4,at a single autosomal gene locus.These alleles determine the six phenotypes E2/2,E3/3,E4/4,E4/2,E4/3,and E3/2.Results In Uygur population,the frequency of thee2,e3ande4are0.221±0.373,0.647±0.380and0.132±0.224respectively.In Han population,the frequency of thee2,e3ande4are0.081±0.196,0.772±0.315and0.146±0.237respectively.In the patient group,the frequency of thee2,e3ande4are0.073±0.215,0.777±0.311and0.151±0.241respectively.In the control group,the frequency of thee2,e3ande4are0.185±0.296,0.685±0.367and0.130±0.221respectively.e2frequency of Uygur'patient and control are0.105±0.315and0.367±0.296 respectively.Serum LDL cholesterol,TC and TG values tended to decrease from the Apo E-4phenotypes to Apo E-2phenotypes.Deletion polymorphism ofe2compared with common risk factors for CAD,its risk ratio(RR)is3.45.Conclusions These studies confirm and extend that the Apo E phenotype distribution in Uygur population differed significantly from Han population in Xinjiang.CAD patients have significantly lowere2allele and slightly highere3ore4allele frequency than controls especially in Uygur population.Deletion ofe2may be a risk factor for CAD." @default.
- W2373446181 created "2016-06-24" @default.
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- W2373446181 date "2004-01-01" @default.
- W2373446181 modified "2023-09-28" @default.
- W2373446181 title "Study of Apolipoprotein E Gene Polymorphisms in Xinjiang Uygur and Han Patients with Coronary Artery Disease" @default.
- W2373446181 hasPublicationYear "2004" @default.
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