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- W2373447289 abstract "Objective To explore some certain processes and effects of lysolecithin choline (LPC) in the pathogenesis of pancreatic encephalopathy (PE).Methods SD rats were divided into test group,control group 1 and control group 2 at random.Acute edematous pancreatitis models were induced according to the Aho HJ method for test group and control group I.The rate in test group were subjected to the intravenous injection of LPC,while those in the control group I to saline via tail vein.The rats in control group 2 were subjected to the intravenous infection of LPC with pseudo-operation.Horseradish peroxidase (HRP) was used as a tracer to determine if the blood-brain barrier (BBB) was open 7-10 days after successive application of LPC for 5 days.The extravasated tracer was showedby diaminobenzidine (DAB).Rats' brain tissue sections were examined by ponceau stain and Luxol Fast Blue stain to determine whether the brains were demyelinated at the same time.Results In test group,the BBB permeability of the rats was increased greatly and obvious demyelination was observed in brains,while in both control groups the rats had basically intact BBB and scarce demyelination.There was statistical difference between the test group and control groups.Conclusion LPC increase the BBB permeability and demyelinates the brain on pancreatitis models,suggesting that LPC might play an important role in the pathogenesis of PE." @default.
- W2373447289 created "2016-06-24" @default.
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- W2373447289 date "2005-01-01" @default.
- W2373447289 modified "2023-09-23" @default.
- W2373447289 title "Effects of lysophosphatidyl choline on the pathogenesis of pancreatic encephalopathy" @default.
- W2373447289 hasPublicationYear "2005" @default.
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