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- W2373448203 abstract "Objective To evaluate the value of serum galactomannan(GM) Platelia Aspergillus Kit in the diagnosis and prediction of invasive fungal infection(IFI) in patients with hematologic malignancy.MethodsA total of 254 serum samples from 83 high risk patients were collected.ELISA assay was used to analyze the change of GM antigen.ResultsAccording to the certainty level of IFI diagnosis,3,5,23 and 5 patients were identified as GM positive in proven,probable,possible and improbable IFI groups respectively.The prevalence of GM in these 4 groups was 75%,63%,51% and 19%,respectively.The sensitivity and specificity of galactomannan ELISA assay were 67% and 81% respectively.The positive and negative predictive values were 62% and 84% respectively.The efficacy of amphotericin B or itraconazole in GM-positive patients was superior to that of fluconazole.In GM-negative patients,the efficacy of these three drugs did not show significant difference.After antifungal therapy,the average OD value of GM-positive patients decreased from 1.65 ± 0.85 to 0.58 ± 0.30(P0.05).But in GM negative patients,the value was 0.25 ± 0.10 and 0.26 ± 0.20,respectively(P0.05).ConclusionsThe sensitivity of galactomannan ELISA assay is moderate,but with high specificity.The high-risk patients whose GM test is positive should begin antifungal therapy immediately.However,negative result can not exclude IFI.The change of GM values can be considered as a reliable index to predict the antifungal effect." @default.
- W2373448203 created "2016-06-24" @default.
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- W2373448203 date "2009-01-01" @default.
- W2373448203 modified "2023-09-23" @default.
- W2373448203 title "Utility of serum galactomannan in diagnosis of invasive fungal infection in hematologic malignancy" @default.
- W2373448203 hasPublicationYear "2009" @default.
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