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- W237348079 abstract "Despite its maternal protection, the development of the mammalian embryo is governed by a constant interplay of hereditary and environmental factors. The genetic information contains the programmation of the whole phenotype of the future baby, the environment supplies the nutrients necessary for growth and differentiation. Hence the expression of the inherited genes depends on exogenous factors. They can modify or prevent the development of genetically determined structures, leading to congenital malformations or to the death of the embryo. However, very complex conditons have to be fulfilled in order to compete with the various mechanisms which control human prenatal development. The action of a teratogenic agent on the conceptus depends mainly on three conditions: the developmental stage of the embryo the genetic susceptibility of the embryo, and the physiological and pathological status of the mother. The effects of noxious agents on the embryo are irreversible the growing organism being incapable of repairing even very short injuries during its subsequent development. The determination of the teratogenic potential of drugs, pesticides and other exogenous agents is based on experimental data and epidemiological investigations. The influence of various agents will be reviewed. In recent years it has been shown that there is not a direct relationship between the chemical structure, the pharmacological activity or the toxicity of a drug in the adult and its specific action on the embryo. The prospects of detection of environmental teratogenic agents are favourable. As more experience is gained preventive measures should become a possibility." @default.
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- W237348079 date "1977-01-01" @default.
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- W237348079 title "INFLUENCE DE L'ENVIRONNEMENT SUR LA DESCENDANCE" @default.
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- W237348079 doi "https://doi.org/10.1016/b978-0-08-021998-1.50015-4" @default.
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