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- W2373490722 abstract "Objective: To observe the expression of CD14 protein and its mRNA on Kupffer cells (KCs) and evaluate the role of CD14 protein in the pathogenesis of liver injury in the rats with alcohol-induced liver disease (ALD). Methods: Twenty eight Wistar rats were divided into two groups: ethanol-fed group and control group. Ethanol-fed group were fed ethanol(dose of 5~12/kg/24h) and control group received dextrose instead of ethanol. Two groups were sacrificed at 4w and 8w. KCs were isolated and expression of CD14 protein and its mRNA on KCs were determined with flow cytometric (FCM) analysis or the reverse transcription polymerase chain reaction (RT-PCR) analysis. Levels of tumor necrosis factor (TNF)-α and interleukin(IL)-6 in plasma were determined with enzyme linked immunosorbent assay (ELISA). Levels of endotoxin and alanine transaminase(ALT) in blood were measured also, and liver pathology was observed under light and electron microscopy. Results: In ethanol-fed rats, ethanol administration led to a significant expression in CD14 protein and its mRNA compared with the control group(P0.05) at 8 week. In ethanol group, concentrations of TNF-α, IL-6 and plasma endotoxin levels were increased dramatically than in the control rats at two time points. In liver section from ethanol-fed rats, there was marked pathological changes but there was no change in control group. Conclusion:In ethanol-fed rats, ethanol administration led to a significant expression of CD14 protein and its mRNA, and increase of TNF-α and IL-6 levels, which may result in the pathological changes of liver tissue and hepatic functional damages." @default.
- W2373490722 created "2016-06-24" @default.
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- W2373490722 date "2002-01-01" @default.
- W2373490722 modified "2023-09-23" @default.
- W2373490722 title "The expression of lipopolysaccharide receptor CD14 protein on Kupffer cells of the rats with alcoholic liver disease" @default.
- W2373490722 hasPublicationYear "2002" @default.
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