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- W2373501722 abstract "Objective To evaluate the effect of intraoperative continuous nimodipine infusion on cerebral oxygen supply-consumption balance during supratentorial tumor resection.Methods Thtuenty-four ASA gradeⅠorⅡpatients aged 18~65 year undergoing excision of supratentorial glioma were randomly divided into 2 groups: nimodipine group(A,n=12) and control group(B,n=12).Patients in group B were given continuous nimodipine infusion [15 μg/(kg·h)] before induction of anesthesia.Patients in group A were given continuous saline infusion [0.075 mL/(kg·h)].Systemic hemodynamics was monitored during operation.Left common carotid vein retrograde catheterization(deep sigmoid sinus) and dorsalis pedis artery puncture were performed under local anesthesia.Blood samples were taken from artery and jugular venous bulb immediately before induction of anesthesia(T1,baseline),at intubation(T2),immediately before opening of dura(T3),1h after opening of dura(T4),at the closure of dura(T5),and 24h after operation(T6) for blood gas analysis and the result was recorded or calculated for Hb,SaO2,SjvO,PaO2,PjvO2,CaO2,CjvO2,Ca-jvO2,CERO2.Results (1) CaO2,CjvO2,PjvO2,SjvO2 at T2 were significantly higher than those at T1(P0.01).Ca-jvO2,CERO2 at T2 were significantly lower than at T1(P0.01).CaO2,CjvO2,PjvO2,SjvO2,Ca-jvO2 at T6 were significantly lower than those at T1(P0.01).CERO2 at T6 was significantly higher than that at T1(P0.05,P0.01).The differences were statistically significant.(2)At T6 time point,CjvO2 and SjvO2 in group B were significantly higher than that in group A(P0.05,P0.01);Ca-jvO2 and CERO2 were significantly lower than those in group A(P0.01).The differences were statistically significant.(3) There were no statistically differences between intra-group comparison and between the two groups in other parameters.Conclusion Nimodipine infusion does not influence cerebral oxygen of supply-consumption in patients with supratentorial tumor during operation,but it improves cerebral oxygen of supply-consumption on the first day after operation." @default.
- W2373501722 created "2016-06-24" @default.
- W2373501722 creator A5024677474 @default.
- W2373501722 date "2009-01-01" @default.
- W2373501722 modified "2023-09-23" @default.
- W2373501722 title "Effect of intraoperative continuous nimodipine infusion on cerebral oxygen supply-consumption balance during supratentorial tumor resection" @default.
- W2373501722 hasPublicationYear "2009" @default.
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