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- W2373504206 abstract "Objective: To study the genotoxicity and antitumor activity of a Chinese medicinal herb, Triptery-gium Hypoglaucum (Level) Hutch (THH). Methods: The genotoxicity and antitumor activity of THH were investigated in human promyelocytic leukemia cells on the mutation of hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene by using single cell clone culture, two-way screening counting, multiplex PCR amplification and gel electrophoresis. Results: The results showed that different mutant spectra existed between the spontaneous mutation and induced mutation by THH. Only 7. 7% (1/13) of spontaneous mutants showed deletion mutations, whereas the induced mutants included 46. 6% (27/58) deletions. Mapping of all intra-genic deletion breakpoints showed a random distribution in all 9 exons, but toward the 3'-end of the HPRT gene. Deletion of exon 1 only appeared when whole gene was deleted. Deletions of exon 7/8 and 9 often showed linkage deletions (71. 4%). Conclusion: THH can induce the mutation, mainly deletions, of HPRT gene in human promyelocytic leukemia cells." @default.
- W2373504206 created "2016-06-24" @default.
- W2373504206 creator A5053696556 @default.
- W2373504206 date "2002-01-01" @default.
- W2373504206 modified "2023-09-24" @default.
- W2373504206 title "Molecular analysis of THH-induced mutations at HPRT locus in human promyelocytic leukemia cells with multiplex polymerase chain reaction" @default.
- W2373504206 hasPublicationYear "2002" @default.
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