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- W2373508744 abstract "Objective To analyze the correlation of changes in procalcitonin(PCT)and galactomannan(GM)levels with invasive aspergillosis(IA)in elderly patients,and to provide a basis for timely diagnosis,treatment and nursing care.Methods Sixty-five elderly IA patients were divided into IA group(n=40)and sepsis group(n=25).The diagnosis met the Chinese Diagnostic Criteria for Fungal Infection and European Diagnostic Criteria for Cancer Therapy and Invasive Fungal Infection.In addition,50healthy subjects were enrolled as normal controls(control group).Fasting venous blood samples(3mL)were collected to obtain serum samples and levels of GM and PCT were determined by ELISA using mini-VIDAS.The examination results were compared among the three groups.Results Compared with IA group,PCT levels decreased in control group but increased in sepsis group(P0.05).Compared with sepsis group or control group,GM levels increased in IA group(P0.05).No significant differences in GM levels were found between sepsis group and control group(P0.05).The area under the curve(AUC)for GM was significantly greater than that for PCT(0.935vs 0.861,P0.05),indicating that the diagnostic efficiency of GM was greater than PCT.Compared with IA group,the positive PCT detection rate decreased in control group but increased in sepsis group(4.0ng·mL-1 vs 45.0ng·mL-1 and 4.0ng·mL-1 vs 84.0ng·mL-1,respectively;P0.05).Compared with sepsis group and control group,the positive GM detection rate increased in IA group(77.5pg·mL-1 vs 8.0pg·mL-1 and 77.5pg· mL-1 vs 2.0pg·mL-1,respectively;P0.05).The positive PCT detection rate was significantly lower than the positive GM detection rate in IA group(P0.05).Conclusion GM detection has higher specificity for the diagnosis of aspergillus infection.Medium-low levels of PCT indicate that aspergillus infection occurs and PCT level increases in elderly patients." @default.
- W2373508744 created "2016-06-24" @default.
- W2373508744 creator A5079291607 @default.
- W2373508744 date "2014-01-01" @default.
- W2373508744 modified "2023-09-23" @default.
- W2373508744 title "Correlation of Changes in Serum Procalcitonin and Galactomannan Levels with Invasive Aspergillosis in Elderly Patients" @default.
- W2373508744 hasPublicationYear "2014" @default.
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