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- W2373522182 abstract "To investigate systemic effects of sulfur dioxide inhalation on animals,ultrastructures of brains, hearts,kidneys and testicles were observed with electron microscopy after the mice exposed to SO_ 2 at 28.00±1.98 and 56.00±3.11 mg·m -3. The results showed : (1) For brains, some of the cerebral cortex neurons,many glialcells and nerve fiber were damaged by SO_ 2; Nuclear aberrations, increase of endoplasmic reticulum, and mitochondrial swellings caused by SO_ 2 exposure were observed in these cells; (2) For hearts, mitochondrial swellings, decreases or disappearances of mitochondria crista, myocardial myofibril disorders, various changes of nucleus and chromatin, intercalated disc dissociations, endothelium edema in heart tissues in both SO_ 2 exposed groups. In addition to above changes, myofibrillar fragmentation and dissolution, myocardial cell membrane breachage and inflammatory cell infiltration were observed in SO_ 2 56 mg·m -3 group; (3) For kidneys, SO_ 2 exposure exerted serious lesions on ultrastructures in renal proximal tubular lining cells, meanwhile it damaged glomerulus and distal tubular lining cells; Increases of endoplasmic reticulum and mitochondrial swellings were observed; The changes of 56mg·m -3 SO_ 2 group were more serious than the 28mg·m -3 group, decreases and disappearances of mitochondrial crista were found in 56mg·m -3 SO_ 2 group;(4) For testicles, compared with control group, the basement membranes, various seminiferous cells, spermatozoa, sertoli cells of testicles were changed in both SO_ 2-exposed groups. The changes caused by SO_ 2 at 56 mg·m -3 were more serious than the 28 mg·m -3 SO_ 2 group. These results proved that SO_ 2 might cause ultrastructural changes in multiple organs from mice; it provided pathologic and morphologic evidences for our view that SO_ 2 was a systemictoxic agent." @default.
- W2373522182 created "2016-06-24" @default.
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- W2373522182 date "2006-01-01" @default.
- W2373522182 modified "2023-09-23" @default.
- W2373522182 title "Effects of sulfur dioxide inhalation on ultrastructures of brains, hearts, kidneys and testicles from mice" @default.
- W2373522182 hasPublicationYear "2006" @default.
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