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- W2373523855 abstract "Objective To establish heart-specific D5F173L transgenic mice and to investigate the mechanism of dopamine D5 receptor in cardiac hypertrophy. Methods The transgenic plasmid was constructed by inserting the human D5F173L gene into the down-stream of α-MHC promoter. The transgenic mice were generated by microinjection. The genotype of transgenic lines was identified by PCR, and the expression levels of the D5 receptor were detected by Western Blotting. The functional and pathologic changes of the heart were analyzed by echocardiography and observed by microscopy. Results The heart-specific D5F173L transgenic mice with high expression levels of D5 receptor were established. Compared with the negative controls, the systolic and diastolic volume and inner diameter of left ventricle of the transgenic mice were greater [volume (44.97±14.54) vs (24.66±5.34)μL, (83.99±18.42) vs (64.83±9.90)μL; inner diameter: (3.26±0.42) vs (2.58±0.23), (4.28±0.39) vs (3.86±0.25)mm; all P0.05] and the ejection fraction and the fraction shortening decreased [(48.01±8.73)% vs (62.18±4.84)%, (24.23±5.15)% vs (33.15±3.52)%, both P0.05]. Conclusion The heart-specific D5F173L transgenic mice suffer from dilated cardiomyopathy." @default.
- W2373523855 created "2016-06-24" @default.
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- W2373523855 date "2011-01-01" @default.
- W2373523855 modified "2023-09-26" @default.
- W2373523855 title "Over-expression of D5F173L in heart tissue causes dilated cardiomyopathy in the transgenic mice" @default.
- W2373523855 hasPublicationYear "2011" @default.
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