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- W2373529854 abstract "AIM: To explore the influence of norcantharidin on invasion of GBC-SD cells in human gallbladder carcinomas and inhibitory effect of the related genes. METHODS: GBC-SD cells of human gallbladder carcinoma were cultured by cell culture technique. The Matrigel experiment and the crossing-river test were used to examine the inhibitory effect of norcantharidin on invasion of GBC-SD cells. The influence on expression of MMP_2 and TIMP_2 proteins of GBC-SD cells was determined by streptavidin-biotin complex method before and after the treatment with norcantharidin. RESULTS: The Matrigel experiment showed that norcantharidin began to inhibit the invasion of GBC-SD cells at the concentration of 5 mg·L -1 ,and it could completely inhibit the invasive action of GBC-SD cells at 40 mg·L -1 .The crossing-river test indicated the crossing-river time of GBC-SD cells treated with norcantharidin (40 mg·L -1 ) for 72 h became long significantly. The expression of MMP_2 gene proteins and the ratio of MMP_2/TIMP_2 of GBC-SD cells decreased significantly,and expression of TIMP_2 increased( P 0.01 ). CONCLUSION: Norcantharidin can inhibit the invasive capability of GBC-SD cells in human gallbladder carcinomas. The mechanism may correlate with inhibition of GBC-SD cell movement and influence of the expression of MMP_2 and TIMP_2 of GBC-SD cells." @default.
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- W2373529854 date "2004-01-01" @default.
- W2373529854 modified "2023-09-27" @default.
- W2373529854 title "Influence of norcantharidin on invasion of GBC-SD cells in human gallbladder carcinomas and inhibitory effect of related genes" @default.
- W2373529854 hasPublicationYear "2004" @default.
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