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- W2373535269 abstract "Objective To observe the effect of breviscapine on the open probability(Po)and the average open time(To) of L-type calcium channel in the hippocampal neurons of the whole brain ischemia-reperfusion rat model.Methods The whole brain ischemia rat model was established.At the reperfusion periods of 1.5 h,3.0 h,4.5 h and 6.0 h,the hippoeampal CA1 neurons were dissociated abruptly and the Ca~(2+)electricity of single channel on the neuron membrane were recorded with cell-attach model of patch clamp techniques.The Po and To of the L-type calcium channel were an- alyzed and the effect of the breviscapine was observed.Results Different concentrations of breviscapine can decrease the Po and To of the L-type calcium channel in hippoeampal neurons,particularly within 3 hours after ischemia-reperfu- sion.Conclusions Breviscapine has protective effect on the cerebral ischemia-reperfusion injury." @default.
- W2373535269 created "2016-06-24" @default.
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- W2373535269 date "2006-01-01" @default.
- W2373535269 modified "2023-09-24" @default.
- W2373535269 title "Effect of Breviscapine on L-type Calcium Channel in the Hippocampal CA1 Neurons of Whole Brain Ischemiareperfusion Rat Model" @default.
- W2373535269 hasPublicationYear "2006" @default.
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