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- W2373551214 abstract "Objective To study the effect of Huaier granule on the recurrence and metastasis of hepatocellular carcinoma(HCC)and immune rejection in the postoperative patients with liver transplantation for HCC.Methods Twenty-eight patients of liver transplantation for HCC who had taken Huaier granule orally for more than 6 months from September 2001 to March 2007 in West China Hospital were included as treatment group,and other 56 patients of liver transplantation for HCC who didn't take any Huaier granule in the same time were included as the control group according to the same stage of TNM,degree of tumor differentiation(Edmondson grading)respectively with the treatment group.The method of retrospective cohort study was used to compare the incidence of immune rejection and the 6-month,1-year,and 2-year recurrence and metastasis of HCC,disease free survival rate,and survival rate between two groups after 2 years' follow-up beginning from the date of surgery.Results The 6-month,1-year,and 2-year tumor recurrence and metastasis incidences in treatment group were 14.3%,32.1%,and 39.3% respectively,which were 23.2%,32.1%,and 50.0% respectively in control group,and the 2-year tumor recurrence and metastasis incidence of the treatment group was lower than that of the control group.The 6-month,1-year,and 2-year disease free survival rates in treatment group were 85.7%,67.5%,and 60.0% respectively,which were 76.7%,67.6%,and 49.3% respectively in control group,and the 2-year disease free survival rate of treatment group was higher than that of the control group.The 6-month,1-year,2-year survival rates in treatment group were 92.9%,78.6%,and 67.9% respectively,which were 89.3%,75.0%,and 62.5% respectively in control group.But the 2-year tumor recurrence and metastasis incidence(P=0.353),2-year disease free survival curve(P=0.386),and 2-year survival curve(P=0.620)were not significantly different between two groups.The incidence of immune rejection was 14.29% in the treatment group and 16.07% in the control group,which was not significantly different between the two groups(P=0.831).Conclusions Huaier granule can increase the 2-year tumor-free survival rate and restrain the recurrence and metastasis of HCC,and does not increase the incidence of immune rejection.Huaier granule as a treatment of HCC in patients with liver transplantation is safe and effective." @default.
- W2373551214 created "2016-06-24" @default.
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- W2373551214 date "2010-01-01" @default.
- W2373551214 modified "2023-09-25" @default.
- W2373551214 title "Retrospective Cohort Study on Clinical Value of Huaier Granule in Postoperative Patients with Liver Transplantation for Hepatocellular Carcinoma" @default.
- W2373551214 hasPublicationYear "2010" @default.
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