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- W2373555985 abstract "Objective:To investigate the effects of hydrogen sulfide(H2S)on action potentials(Ap)of rabbit left ventricular myocytes.Methods:By using standard intracellular microelectrode technique to record Ap,hydrogen sulfide was used to investigate the electrophysiological features of left ventricular myocytes.Electrophysiological parameters examined were:RP(resting potential),APA(amplitude of action potential),Vmax(maximal rate of depolarization),OS(over-shoot),APD20,APD50 and APD90(20%,50% and 90% of duration of action potential)and average rate of repolarization.Results:(1)Perfusion with NaHS(H2S donor,50μmol/L)led to a significant decrease in APD50(P0.01),APD90(P0.01)and a significant increase in average rate of repolarization(P0.05).(2)Application of 100μmol/L NaHS resulted in a significant shortening in APD50(P0.01),APD90(P0.01)and a significant increase in average rate of repolarization(P0.05).Compared with the result of 50μmol/L NaHS,100μmol/L NaHS led to a significant shortening in APD50(P0.01),APD90(P0.05)and a significant increase appeared in average rate of repolarization(P0.05).(3)Application of 200μmol/L,400μmol/L and 1 000μmol/L NaHS led to a significant decrease in APA,RP and OS,a significant shortening in APD20,APD50 and APD90,a significant increase in average rate of repolarization in a concentration-depedent manner.Conclusion:H2S could significantly affect the electrophysiology of guinea pig ventricular myocytes in a concentration-depedent manner." @default.
- W2373555985 created "2016-06-24" @default.
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- W2373555985 date "2009-01-01" @default.
- W2373555985 modified "2023-09-23" @default.
- W2373555985 title "Effects of Hydrogen Sulfide on Electrophysiological Features of Rabbit Ventricular Myocytes" @default.
- W2373555985 hasPublicationYear "2009" @default.
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