Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373556497> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2373556497 abstract "Objective To investigate the effect of carbon monoxide derived from hemeoxygenase-1(HO-1) metabolism on CYP2E1(cytochrome p4502E1) activity,and the protective role on ethanol-induced oxidative stress mediated by CYP2E1.Methods Liver microsomes isolated form Sprague-Dawley rat using ultracentrifugation technique,were treated with hemin,Hb or different dose of carbon monoxide-releasing molecule-2(CORM-2) and the catalytic activity of CYP2E1 was detected.In addition,the activity of superoxide dismutase(SOD),as well as the levels of glutathione(GSH),malondialdehyde(MDA) and reactive oxygen species(ROS) were assayed when incubated with hemin,Hb or CORM-2.Results Hemin treatment significantly inactivated CYP2E1,which was mimicked by CORM-2 in dose-dependent manner but blocked by Hb.Furthermore,hemin and CORM-2 evidently inhibited the increase of MDA and ROS,and the GSH depletion and SOD inactivation in microsomes induced by ethanol.Likewise,Hb abolished the protective effect of hemin and inactivated CORM-2 failed to exhibit any protective role.Conclusion Carbon monoxide prevented mcrosomes from ethnol-induced oxidative stress,which might be involved in its direct inhibition on CYP2E1." @default.
- W2373556497 created "2016-06-24" @default.
- W2373556497 creator A5019797064 @default.
- W2373556497 date "2012-01-01" @default.
- W2373556497 modified "2023-09-28" @default.
- W2373556497 title "CARBON MONOXIDE PROTECTS MICROSOMES FROM ETHANOL-DERIVED OXIDATIVE STRESS MEDIATED BY CYP2E1" @default.
- W2373556497 hasPublicationYear "2012" @default.
- W2373556497 type Work @default.
- W2373556497 sameAs 2373556497 @default.
- W2373556497 citedByCount "0" @default.
- W2373556497 crossrefType "journal-article" @default.
- W2373556497 hasAuthorship W2373556497A5019797064 @default.
- W2373556497 hasConcept C140027455 @default.
- W2373556497 hasConcept C181199279 @default.
- W2373556497 hasConcept C185592680 @default.
- W2373556497 hasConcept C2775838275 @default.
- W2373556497 hasConcept C2776151105 @default.
- W2373556497 hasConcept C2776217839 @default.
- W2373556497 hasConcept C2777723881 @default.
- W2373556497 hasConcept C2778401633 @default.
- W2373556497 hasConcept C2780161600 @default.
- W2373556497 hasConcept C48349386 @default.
- W2373556497 hasConcept C538909803 @default.
- W2373556497 hasConcept C55493867 @default.
- W2373556497 hasConcept C86803240 @default.
- W2373556497 hasConcept C87644729 @default.
- W2373556497 hasConcept C98274493 @default.
- W2373556497 hasConceptScore W2373556497C140027455 @default.
- W2373556497 hasConceptScore W2373556497C181199279 @default.
- W2373556497 hasConceptScore W2373556497C185592680 @default.
- W2373556497 hasConceptScore W2373556497C2775838275 @default.
- W2373556497 hasConceptScore W2373556497C2776151105 @default.
- W2373556497 hasConceptScore W2373556497C2776217839 @default.
- W2373556497 hasConceptScore W2373556497C2777723881 @default.
- W2373556497 hasConceptScore W2373556497C2778401633 @default.
- W2373556497 hasConceptScore W2373556497C2780161600 @default.
- W2373556497 hasConceptScore W2373556497C48349386 @default.
- W2373556497 hasConceptScore W2373556497C538909803 @default.
- W2373556497 hasConceptScore W2373556497C55493867 @default.
- W2373556497 hasConceptScore W2373556497C86803240 @default.
- W2373556497 hasConceptScore W2373556497C87644729 @default.
- W2373556497 hasConceptScore W2373556497C98274493 @default.
- W2373556497 hasOpenAccess W2373556497 @default.
- W2373556497 hasRelatedWork W1978589242 @default.
- W2373556497 hasRelatedWork W1978987336 @default.
- W2373556497 hasRelatedWork W1981388447 @default.
- W2373556497 hasRelatedWork W1995281155 @default.
- W2373556497 hasRelatedWork W2001036834 @default.
- W2373556497 hasRelatedWork W2004092146 @default.
- W2373556497 hasRelatedWork W2012622793 @default.
- W2373556497 hasRelatedWork W2013925827 @default.
- W2373556497 hasRelatedWork W2017529874 @default.
- W2373556497 hasRelatedWork W2030834862 @default.
- W2373556497 hasRelatedWork W2044646443 @default.
- W2373556497 hasRelatedWork W2051311589 @default.
- W2373556497 hasRelatedWork W2052170653 @default.
- W2373556497 hasRelatedWork W2078237723 @default.
- W2373556497 hasRelatedWork W2086854157 @default.
- W2373556497 hasRelatedWork W2135057523 @default.
- W2373556497 hasRelatedWork W2374911200 @default.
- W2373556497 hasRelatedWork W2988546173 @default.
- W2373556497 hasRelatedWork W3042421931 @default.
- W2373556497 hasRelatedWork W2552514942 @default.
- W2373556497 isParatext "false" @default.
- W2373556497 isRetracted "false" @default.
- W2373556497 magId "2373556497" @default.
- W2373556497 workType "article" @default.