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- W2373556799 abstract "Objective: To evaluate the role of CDK4 and p16 protein expression in nasopharyngeal carcinoma (NPC). Methods: The S-P immunohistochemical method was used to detect the expression of CDK4 and p16 protein in 60 cases of NPC and 20 cases of normal tissues. Results:The positive expression rates of CDK4 and p16 protein in NPC were 66. 7% and 23. 3%, respectively. The positive expression rate of p16 protein was higher in well differentiated squamous cell carcinoma than in poorly differentiated squamous cell carcinoma (P 0. 01 ). A significant correlation was found between low expression of p16 protein, over expression of CDK4 protein and cervical lymph node metastasis (P 0.05 ). Conclusions: The results suggest that the inactivation of p16 protein and over expression of CDK4 protein may be involved in the carcinogenesis and development of NPC and implicated in tumor defferentiation and metastasis." @default.
- W2373556799 created "2016-06-24" @default.
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- W2373556799 date "2000-01-01" @default.
- W2373556799 modified "2023-09-27" @default.
- W2373556799 title "A study of CDK4 and p16 protein in nasopharyngeal carcinoma" @default.
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