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- W2373565280 abstract "Objective:To investigate the expressions of developmental related genes and their relationship with clinical features and prognosis in childhood acute lymphoblastic leukemia(ALL).Methods:The mRNA expressions of Notch1,Wnt3a and β-catenin genes were detected by quantitative real-time RT-PCR in bone marrow mononuclear cells from 125 patients with newly diagnosed childhood ALL(ALL group),and analyzed the correlation to clinical characteristics(age,gender,WBC count,FAB classification,immunophenotype and clinical risk stratification).Twenty sex-and age-matched patients without malignant hematological diseases enrolled in this study as the control group.Results:The mRNA expressions of Notch1,Wnt3a and β-catenin were detected in all the bone marrow samples of childhood ALLs and control patients.Compared with the control group,mRNA expressions of Notch1 gene were remarkably lower(P 0.05),but the expressions of β-catenin gene were much higher(P0.05)in ALL group.However,expressions of Wnt3a mRNA had no significant difference between ALL and control group(P0.05).The expressions of Notch1 gene were higher in T-ALL than control group(P0.05),and were lower in B-ALL than control group(P0.05).In addition,the high expressions of β-catenin gene were significantly associated with age(1 or 10 years)and higher leukocyte count(≥50×109/L)(P0.05),and were not associated with either of gender,FAB classification,immunophenotype and clinical risk stratification(P0.05).Conclusion:The abnormal expressions of Notch1 and β-catenin in childhood ALL might play an important role in the pathogenesis of childhood ALL.The high expressions of β-catenin gene might be associated with poor prognosis in childhood ALL.Examination of Notch1 and β-catenin mRNA might be a new target for diagnosis and treatment of childhood ALL." @default.
- W2373565280 created "2016-06-24" @default.
- W2373565280 creator A5013411080 @default.
- W2373565280 date "2011-01-01" @default.
- W2373565280 modified "2023-09-23" @default.
- W2373565280 title "The expression and significance of developmental related genes in childhood acute lymphoblastic leukemia" @default.
- W2373565280 hasPublicationYear "2011" @default.
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