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- W2373569435 abstract "Objective To explore the effects of irbesartan on activities of Na~+-K~+-ATPase,Ca~(2+)-ATPase and level of Ang Ⅱ in kidney of RHR.Methods Renovascular hypertension was induced by two kidney-one clip method.Eighteen RHR were randomly divided into RHR group (Mod), irbesartan group(Irb) and discontinuation of medication group(Dis).Other 6 SD rats served as sham operation group(Sha).ATPase activity and Ang Ⅱ content in renal cortexes of RHR were determined by spectrophotometry and radioimmunoassay respectively after 8 weeks of irbesartan treatment.Results Compared with Sha,the activities of Na~+-K~+-ATPase of bilateral renal cortexes were significantly lower,plasma AngⅡ level was significantly higher in Mod,Irb and Dis,the activity of Ca~(2+)-ATPase was significantly lower in Mod and Dis.Compared with Mod,the activity of Ca~(2+)-ATPase significantly increased in Irb,plasma Ang Ⅱ significantly higher in Irb and Dis. Compared with Irb,the activity of Ca~(2+)-ATPase decreased and Ang Ⅱ level significantly increased in Dis.There was a significant negative correlation between Ang Ⅱ and the activity of Ca~(2+)-ATPase in kidney.Conclusions Irbesartan influences the activity of Ca~(2+)-ATPase and level of Ang Ⅱ in kidney of RHR.The Ang Ⅱ and activity of Ca~(2+) -ATPase are in disorder after discontinuation of medication,which might be one of the mechanisms of rebound of hypertension." @default.
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- W2373569435 date "2010-01-01" @default.
- W2373569435 modified "2023-09-23" @default.
- W2373569435 title "Effects of irbesartan on ATPase activity and AngII in kidney of renal hypertensive rats" @default.
- W2373569435 hasPublicationYear "2010" @default.
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