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- W2373570057 abstract "Membrane markers on human lymphocytes separated from fetal liver and spleen were studied.Depending on the period of intrauterine development, a growing percentage of T- and Blymphocytes (up to 16 % and 45 %, respectively) among spleen cells was seen, but in liver the number was low independent of the gestational age (T cells < 10 % and B cells < 15 %).The majority of early CD3+ spleen cells (21st–28th week) expressed TCRαβ but not TCRγδ, although a significant proportion of these cells was still lacking CD4, CD8, and CD5 differentiation antigens, suggesting their immaturity.Later spleen T cells (29th–36th week) expressed the phenotype as mature adult-type T cells (CD3+TCRαβ+CD4/8+CD5+).During ontogeny in fetal spleen, a growing number of B cells could be estimated without any changes in the proportion of subsets, expressing the different light and heavy chains.However, the proportion of CD5+ B cells decreased with gestational age.The results suggest that the functional immaturity of antenatal splenocytes could not be caused by dramatic phenotypical differences in comparison with adult-type splenic lymphocytes." @default.
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- W2373570057 date "1988-01-01" @default.
- W2373570057 modified "2023-09-25" @default.
- W2373570057 title "Aldicarb—immunotoxic or not?" @default.
- W2373570057 doi "https://doi.org/10.1016/0278-6915(88)90133-0" @default.
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