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- W2373572275 abstract "Background:Crohn's disease(CD)is a chronic inflammatory bowel disease caused by excessive proliferation and activation of mucosal reactive T cells.It has been reported recently that regulatory dendritic cells(DCreg)have an intensive inhibitory effect on the proliferation of CD4~+ T cells.Aims:To investigate the therapeutic effect of DCreg on interleukin(IL)-10-deficient mouse model,of which the intestinal pathological changes are similar to those of human CD. Methods:DCreg was induced by mouse endothelial splenic stromal cells from CD117 positive marrow hematopoietic progenitors and its regulatory effect was tested by inhibiting CD4~+ T cells proliferation.DCreg was transferred intraperitoneally into IL-10 gene knockout mice at a dosage of 2×10~6 cells per mouse.The serum levels of IL-6 and tumor necrosis factor(TNF)-αof the treated mice and the controls were tested every week.At the 8th week after treatment,the intestinal tissues were collected to evaluate the histopathological changes and the mucosal levels of IL-6 and TNF-α. Results:After treatment with DCreg,5(62.5%)mice had a slight glandular hyperplasia with few immunocytes infiltrating in the colonic mucosa,3(37.5%)had no colonic mucosal inflammation.However,all the control mice had severe glandular hyperplasia with obvious immunocytes infiltration and fibroblast proliferation.The levels of IL-6 and TNF-αin the serum and the cultured supernatant of colonic mucosal tissues decreased remarkably in the treated mice as compared with those in the controls.Conclusions:DCreg transfer is effective in relieving the IL-10-deficient mice colitis." @default.
- W2373572275 created "2016-06-24" @default.
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- W2373572275 date "2007-01-01" @default.
- W2373572275 modified "2023-09-22" @default.
- W2373572275 title "Therapeutic Effect of Regulatory Dendritic Cells on Interleukin-10-deficient Mouse Colitis Model" @default.
- W2373572275 hasPublicationYear "2007" @default.
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