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- W2373596714 abstract "Objective:To investigate the locomotor stimulant effect of morphine on newly hatched chicks and the role of dopaminergic mechanisms in opioid-induced locomotor sensitization. Methods: Newly hatched male chicks were administrated morphine of various doses (5,10,20 mg·kg -1·d -1, ip) for 7 days and 3 days after cessation of treatment challenged with dopamine reuptake blocker nomifensine (0.5,1 mg·kg -1, ip). Results: Repeated administration of 5 mg·kg -1 morphine significantly elicited progressive locomotor activity relative to saline (P0.001) while 20 mg·kg -1 induced a behavioral depression (P0.05). The locomotor responses to the dopamine reuptake blocker nomifensine were also dose-dependently sensitized in chicks pre-exposed to 5 mg·kg -1morphine(P0.05). Conclusion: Behavioral sensitization to effects of morphine may be highly conserved across species, which supports the possibility that the increased dopaminergic activity is involved in the development of behavioral sensitization to morphine." @default.
- W2373596714 created "2016-06-24" @default.
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- W2373596714 date "2003-01-01" @default.
- W2373596714 modified "2023-09-23" @default.
- W2373596714 title "EFFECTS OF NOMIFENSINE ON LOCOMOTOR SENSITIZATION IN CHICKS PRETREATED WITH MORPHINE" @default.
- W2373596714 hasPublicationYear "2003" @default.
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