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- W2373619984 abstract "Objective To observe the levels of plasma vascular endothelial growth factor(VEGF),stromal cell-derived factor-1α(SDF-1α),the mobilization of endothelial progenitor cell(EPC) and prognosis in patients with acute myocardial infarction(AMI) and type 2 diabetics after treatment with peridopril.Methods Twenty AMI patients with type 2 diabetes mellitus,who underwent percutaneous coronary invention(PCI),were randomly divided into peridopril group(n=10,peridopril 4 mg/d) and control group(n=10,no peridopril).Peripheral blood mononuclear cells(PBMCs) were isolated with density gradient centrifugation.Circulating CD45-/low+/CD34+/CD133+/KDR+ early EPC count in PBMCs were quantified by flow cytometry before PCI and on day 1,3,5,7,14,28 after PCI.Plasma levels of VEGF,SDF-1α and high sensitivity C-reactive protein(hs-CRP) were measured by enzyme linked immunosorbent assay(ELISA).Results The circulating EPC count in perindopril group was significantly more than that in control group at day 7 after PCI([211±78] /1×106 vs.[147±57] /1×106,P 0.05).Compared with that before PCI,EPC was significantly increased at day 5 after PCI in both groups(P0.05).Plasma VEGF level in perindopril group was significantly higher than that in control group at day 5([172±72] ng/L vs.[105±63] ng/L,P0.05) and day 7([183±63] ng/L vs.[77±37] ng/L,P0.05) after PCI,so was the SDF-1α at day 7 after PCI([3 296±680] ng/L vs.[2 115±570] ng/L,P 0.05).However,hs-CRP in perindopril group was significantly lower than that in control group at day 3 after PCI([26.2±6.5] mg/L vs.[33.8±10.6] mg/L,P0.05).Left ventricular ejection fraction(LVEF) in perindopril group was significantly higher than that on admission six month after AMI(0.491±0.059 vs.0.469±0.051,P0.05),but there was no significant difference in LVEF at the two time points in control group(0.482±0.054 vs.0.479±0.052,P0.05).Conclusion Perindopril can improve the abnormal mobilization of SDF-1α and VEGF-EPC after ischemia and the prognosis in AMI patients with type 2 diabetes mellitus." @default.
- W2373619984 created "2016-06-24" @default.
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- W2373619984 date "2012-01-01" @default.
- W2373619984 modified "2023-09-23" @default.
- W2373619984 title "Effect of perindopril on mobilization of endothelial progenitor cells and prognosis in patients with acute myocardial infarction and type 2 diabetes" @default.
- W2373619984 hasPublicationYear "2012" @default.
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