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- W2373653902 abstract "Objective To study the protective effect of Shijingwan agains UV irradiation-induceddamage in ESF-1 cells and its mechanism.Methods The model of photoaging fibroblasts was established by irradiating of ultraviolet light(40J/cm2).The different concentration water-extract solution from Shijingwan were used for photoaging cell.The proliferation of human fibroblasts was detected by MTT,and superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) activity,malondialdehyde(MDA) content were assayed by hydroxylamine,colorimetric and TBA methods respectively.Results The proliferation activity of fibroblasts descended with the UVA irradiation,the activities of SOD and GSH-Px decreased,when the content of MDA was ascensive(P0.01).But under the intervention at middle concentration(100μg/ml) and high concentration(200μg/ml) of water-extract solution from Shijingwan,the above changes induced by UVA irradiation were inhibited(P0.05 or P0.01).Conclusion The water-extract solution from Shijingwan might inhibit the proliferation decreasing which induced by UVA.And its mechanism is due to its abilities of increasing SOD,scavenging oxygen free radicals." @default.
- W2373653902 created "2016-06-24" @default.
- W2373653902 creator A5066082308 @default.
- W2373653902 date "2012-01-01" @default.
- W2373653902 modified "2023-09-24" @default.
- W2373653902 title "Protective effect of Shijingwan on photoaging induced by Ultraviolet A in ESF-1 cell" @default.
- W2373653902 hasPublicationYear "2012" @default.
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