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- W2373663485 abstract "Objective:To study the inhibiting effects of Losartan and Benazepril on left ventricular hypertrophy and Mitogen Activated Protein Kinase(MAPK) in rats Methods: Spontaneously hypertensive rats(SHRs) were randomly divided into three groups:SHRs control group,Benazepril group(10 mg·kg -1 ·d -1 )and Losartan group(30 mg·kg -1 ·d -1 ) The animals had been treated for 3 months Blood pressure ,endothelin (ET)and angiotensinⅡ(AⅡ)in plasma and left ventricle,MAPK activity in left ventricle and myocardial hypertrophy index were measured Results:Significant dicrease of blood pressure,ET level in plasma and left ventricle ,MAPK activity and marked regression of myocardial hypertrophy were observed in Benazepril group In losartan group,The same results were found except that AⅡ in plasma and left ventricle were still in high level Conclusion:These results suggested that AⅡ,ET and MAPK might be some factors mediating myocardial hypertrophy in SHR Benazepril and Losartan could inhibit the effects of AⅡ, ET and MAPK so as to result in reduction of blood pressure and regression of myocardial hypertrophy" @default.
- W2373663485 created "2016-06-24" @default.
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- W2373663485 date "2002-01-01" @default.
- W2373663485 modified "2023-09-23" @default.
- W2373663485 title "Inhibition of losartan and benazepril on myocardial hypertrophy in rats" @default.
- W2373663485 hasPublicationYear "2002" @default.
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