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- W2373669900 abstract "Aim:To study the role of treating mouse lung cancer model with immunotherapy of melanoma associated antigen gene-12(MAGE-12) DNA vaccine.Methods:A total of 80 mice were equally randomized into 4 groups.The vaccine group, pEGFP-C3 group and NS group were injected tumor tissue suspension of Lewis lung cancer into the right medial muscle of lower limb to establish the animal model.14 days,7 days, and 0 day before tumor tissue suspension injection, groups mentioned above were injected pEGFP-C3-MAGE-12, pEGFP-C3 and normal saline at the same muscles,respectively.The blank control group were injected nothing. The growth of tumor and serum MAGE-12 antibody in mice were investigated.Results:In pEGFP-C3 group, NS group and vaccine group, the survival time were (27.0±0.3) d,(27.2±0.3) d, and(28.9±0.6) d;the size of tumor were (179.775±9.085) mm3,(173.172±9.085)mm3, and(144.923±9.528)mm3; the level of MAGE-12 antibody of vaccine group was(711.16±174.78),while MAGE-12 antibody of the other groups were not detected. Compared with those of pEGFP-C3 group, NS group and the blank control group, the survival time of vaccine group was longer, the size of tumor was smaller(P0.05), the serum level of MAGE-12 antibody was higher(P0.05).Conclusion: MAGE-12 gene vaccine can treat lung cancer by immunotherapy." @default.
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- W2373669900 date "2008-01-01" @default.
- W2373669900 modified "2023-09-24" @default.
- W2373669900 title "Effect of tumor growth and antibody in body of mouse model with Lewis lung tumor using a MAGE-12 gene vaccine" @default.
- W2373669900 hasPublicationYear "2008" @default.
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