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- W2373669954 abstract "Objective To explore the changes and clinical significance of serum vascular endothelial cadherin(VE-cad) and hypersensitive C-reactive protein(hs-CRP) levels in patients with coronary heart disease(CHD). Methods By using enzyme-linked immunosobent assay(ELISA),VE-cad and hs-CRP were measured in 20 patients with acute myocardial infarction(AMI),20 with unstable angina pectoris(UAP),20 with stable angina pectoris(SAP) and 20 controls. Results The serum VE-cad and hs-CRP in CHD were higher than that in the controls(t=6.02,6.27;P0.01).VE-cad and hs-CRP levels were increased in order of SAP,UAP and AMI,the differences among them were significant(F=35.66,36.12;q=4.56-9.83;P0.01).In CHD,serum levels of VE-cad were positively correlated with hs-CRP(r=0.507,P0.01).The area under the ROC curve(AUCROC) of VE-cad and hs-CRP was 0.975 and 0.988,respectively,and their sensitivity and specificity for diagnosis were 0.95,0.90 and 0.95,0.95,respectively.The AUCROC of VE-cad and hs-CRP in UAP was 0.915,0.956,and the sensitivity and specificity for diagnosis were 0.90,0.85 and 0.90,0.95.In SAP,the AUCROC of VE-cad and hs-CRP were 0.801,0.813.Serum VE-cad and hs-CRP had a relatively high diagnostic value for AMI,UAP,the difference between these two parameters was not significant(u=0.357,0.195;P0.05). Conclusion The elevated serum levels of VE-cad and hs-CRP may be associated with the degree of coronary artery lesion,which is of a higher value in identification for the severity of CHD." @default.
- W2373669954 created "2016-06-24" @default.
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- W2373669954 date "2012-01-01" @default.
- W2373669954 modified "2023-09-28" @default.
- W2373669954 title "CHANGES AND CLINICAL SIGNIFICANCE OF VASCULAR ENDOTHELIAL CADHERIN AND HYPERSENSITIVE C-REACTIVE PROTEIN IN PATIENTS WITH CORONARY HEART DISEASE" @default.
- W2373669954 hasPublicationYear "2012" @default.
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