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- W2373670242 abstract "here has been increased interest in endogenously produced hydrogen sulfide(H_2S) as a physiologically important molecule.It is believed that H_2S is the third endogenous signaling gasotransmitter,besides nitric oxide and carbon monoxide.Relatively high endogenous levels of H_2S have been measured in the brains of rats,humans,and bovine,suggesting that H_2S may have a physiological function.Endogenous H_2S can be formed from L-cysteine by pyridoxal-5-phosphate-dependent enzymes,including cystathionine-synthase(CBS).Physiological concentrations of H_2S specifically potentiate the activity of NMDA receptor and alter the induction of long-term potentiation(LTP) in the hippocampus.cAMP mediated pathways may be involved in the modulation of NMDA receptor by H_2S.H_2S can also regulate the release of corticotropin-releasing hormone from the hypothalamus.H_2S also appears to have an effect on the cardiovascular system,acting as a vasorelaxant by increasing potassium-ATP channel currents.H_2S can hyperpolarize cell membranes,relax smooth muscle cells,or decrease neuronal excitability.It may shed light on the pathogenesis of many diseases related to the abnormal metabolism of H_2S.H_2S also inhibits smooth muscle cell proliferation via the mitogen-activated protein kinase pathway and protects neurons against oxidative stress." @default.
- W2373670242 created "2016-06-24" @default.
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- W2373670242 date "2006-01-01" @default.
- W2373670242 modified "2023-09-23" @default.
- W2373670242 title "The researching advancement of relation between gasotransmitter hydrogen sulfide and central nervous system" @default.
- W2373670242 hasPublicationYear "2006" @default.
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