Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373671930> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2373671930 abstract "Objective To explore the effects of Sinomenine (Sin) on phenotype transdifferentiation in renal tubular epithelial cells. Methods Mice primary tubular epithelial cells and cell line (MCT) were cultured in vitro. Model group cells were stimulated by IL-1β(10 ng/ml). The cells of Sin group were co-incubated with Sin(10, 100 ,500μmol/L) simultaneously. The cells without IL-1βand Sin treatment were regarded as control group. The protein expression ofα-smooth muscle actin (SMA) and Vimentin was assessed by immunohistochemistry and Western blotting. The mRNA expression ofα-SMA and Vimentin was examined by RT-PCR. Secretion of matrix metalloproteinases was determined by zymography. Results The mRNA expression and protein level ofα-SMA and Vimentin, and the enzyme activity of MMP-2 and MMP-9 in tubular epithelial cells stimulated with IL-1βwere significantly higher than those in the controls. Sinomenine significantly reduced the expression levels of protein and mRNA ofα-SMA and Vimentin. At the same time, the MMP-2 and MMP-9 activities were reduced markedly. Conclusion Sinomenine can decrease the transdifferentiation in renal tubular epithelial cells stimulated by inflammatory factor IL-1βand prevent renal interstitial fibrosis." @default.
- W2373671930 created "2016-06-24" @default.
- W2373671930 creator A5020403629 @default.
- W2373671930 date "2006-01-01" @default.
- W2373671930 modified "2023-09-23" @default.
- W2373671930 title "Effects of Sinomenine on the expression of cytoskeleton and MMP-2, MMP-9 in renal tubular epithelial cells" @default.
- W2373671930 hasPublicationYear "2006" @default.
- W2373671930 type Work @default.
- W2373671930 sameAs 2373671930 @default.
- W2373671930 citedByCount "0" @default.
- W2373671930 crossrefType "journal-article" @default.
- W2373671930 hasAuthorship W2373671930A5020403629 @default.
- W2373671930 hasConcept C104317684 @default.
- W2373671930 hasConcept C109523444 @default.
- W2373671930 hasConcept C134018914 @default.
- W2373671930 hasConcept C147447768 @default.
- W2373671930 hasConcept C153911025 @default.
- W2373671930 hasConcept C185592680 @default.
- W2373671930 hasConcept C202751555 @default.
- W2373671930 hasConcept C203014093 @default.
- W2373671930 hasConcept C204232928 @default.
- W2373671930 hasConcept C2777662524 @default.
- W2373671930 hasConcept C49039625 @default.
- W2373671930 hasConcept C54355233 @default.
- W2373671930 hasConcept C55493867 @default.
- W2373671930 hasConcept C60870556 @default.
- W2373671930 hasConcept C81885089 @default.
- W2373671930 hasConcept C85265743 @default.
- W2373671930 hasConcept C86803240 @default.
- W2373671930 hasConcept C98274493 @default.
- W2373671930 hasConceptScore W2373671930C104317684 @default.
- W2373671930 hasConceptScore W2373671930C109523444 @default.
- W2373671930 hasConceptScore W2373671930C134018914 @default.
- W2373671930 hasConceptScore W2373671930C147447768 @default.
- W2373671930 hasConceptScore W2373671930C153911025 @default.
- W2373671930 hasConceptScore W2373671930C185592680 @default.
- W2373671930 hasConceptScore W2373671930C202751555 @default.
- W2373671930 hasConceptScore W2373671930C203014093 @default.
- W2373671930 hasConceptScore W2373671930C204232928 @default.
- W2373671930 hasConceptScore W2373671930C2777662524 @default.
- W2373671930 hasConceptScore W2373671930C49039625 @default.
- W2373671930 hasConceptScore W2373671930C54355233 @default.
- W2373671930 hasConceptScore W2373671930C55493867 @default.
- W2373671930 hasConceptScore W2373671930C60870556 @default.
- W2373671930 hasConceptScore W2373671930C81885089 @default.
- W2373671930 hasConceptScore W2373671930C85265743 @default.
- W2373671930 hasConceptScore W2373671930C86803240 @default.
- W2373671930 hasConceptScore W2373671930C98274493 @default.
- W2373671930 hasLocation W23736719301 @default.
- W2373671930 hasOpenAccess W2373671930 @default.
- W2373671930 hasPrimaryLocation W23736719301 @default.
- W2373671930 hasRelatedWork W1972930185 @default.
- W2373671930 hasRelatedWork W1985976115 @default.
- W2373671930 hasRelatedWork W2106887481 @default.
- W2373671930 hasRelatedWork W2303741665 @default.
- W2373671930 hasRelatedWork W2352588725 @default.
- W2373671930 hasRelatedWork W2353794815 @default.
- W2373671930 hasRelatedWork W2354089251 @default.
- W2373671930 hasRelatedWork W2356079176 @default.
- W2373671930 hasRelatedWork W2360183394 @default.
- W2373671930 hasRelatedWork W2361212488 @default.
- W2373671930 hasRelatedWork W2366845981 @default.
- W2373671930 hasRelatedWork W2368812414 @default.
- W2373671930 hasRelatedWork W2370335170 @default.
- W2373671930 hasRelatedWork W2371451121 @default.
- W2373671930 hasRelatedWork W2379056141 @default.
- W2373671930 hasRelatedWork W2387916954 @default.
- W2373671930 hasRelatedWork W2391977456 @default.
- W2373671930 hasRelatedWork W2393394665 @default.
- W2373671930 hasRelatedWork W2474087294 @default.
- W2373671930 hasRelatedWork W3147164685 @default.
- W2373671930 isParatext "false" @default.
- W2373671930 isRetracted "false" @default.
- W2373671930 magId "2373671930" @default.
- W2373671930 workType "article" @default.