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- W2373672010 abstract "Objective:To investigate the intracellular calcium concentration ([Ca 2+] I) alteration induced by Angiotensin Ⅱ(Ang Ⅱ) and platelet derived growth factor (PDGF)-BB in cultured glomerular mesangial cells. Methodology:Rat mesangial cells were cultured. [Ca 2+] I was detected using fluorescentprobe fluo-3/AM and a laser scanning confocal microscope. Results:Both AngⅡ and PDGF-BB significantly increased [Ca 2+] i in a dose-dependent manner, but the temporal pattern and magnitude of the calcium responses were significantly different. AngⅡ-induced elevation in [Ca 2+] i was biphasic. In the initial phase, namely the peak response, [Ca 2+] i increased seven- to eight-fold above baseline, and then rapidly declined to sustained level. However, PDGF-BB-induced was relatively slow, and the peak concentrations were only approximately two-fold above baseline. Correspondence to this, the decline of [Ca 2+] i was also slow, and [Ca 2+] i still higher above baseline till 200 second later. The Ca 2+-free bath and calcium channel blocker nifedipine inhibited the elevation in [Ca 2+] i induced by both AngⅡ and PDGF-BB, but the temporal pattern and magnitude of the inhibitory effect on AngⅡ and PDGF-BB were also significantly different. Conclusion:Ang Ⅱ and PDGF-BB induce [Ca 2+] i elevation in cultured mesangial cells by the different pathways." @default.
- W2373672010 created "2016-06-24" @default.
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- W2373672010 date "2003-01-01" @default.
- W2373672010 modified "2023-09-24" @default.
- W2373672010 title "Angiotensin II and PDGF-BB: Different pathways of changing intracellular calcium concentration in glomerular mesangial cells" @default.
- W2373672010 hasPublicationYear "2003" @default.
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