Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373673375> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2373673375 abstract "Objective: To study the effect of erythromycin derivatives without antibacterial activity on the proliferation of T lymphocytes in vitro and to evaluate their anti-inflammatory mechanism.Methods: T lymphocytes were treated with erythromycin and 9 erythromycin deriva-tives within the dose range of 3 to 100 μg/mL for 24 hours.The inhibitory effects of erythromycin and 9 erythromycin derivatives on the pro-liferation of T lymphocytes cultured in vitro were determined by MTT assay.Results: The proliferation of T lymphocytes was inhibited by ery-thromycin,clarithromycin,N-demethyl erythromycin,9(S)-hydroxyl erythromycin,and 12-membered-ring erythromycin derivative,and 50% inhibitory concentrations(IC50) were 606.28±35.43,431.62±25.60,367.31±32.60,425.62±32.08,and 176.38±10.42 μmol/L,respec-tively.The IC50 of 12-membered-ring erythromycin derivative was significantly lower than that of erythromycin and clarithromycin.Conclusion: Erythromycin and its derivatives could inhibit the proliferation of T lymphocytes,which may be related with the anti-inflammatory activity to some extent." @default.
- W2373673375 created "2016-06-24" @default.
- W2373673375 creator A5027168462 @default.
- W2373673375 date "2006-01-01" @default.
- W2373673375 modified "2023-09-23" @default.
- W2373673375 title "Effects of erythromycin derivatives without antibacterial activity on T lymphocyte proliferation in vitro" @default.
- W2373673375 hasPublicationYear "2006" @default.
- W2373673375 type Work @default.
- W2373673375 sameAs 2373673375 @default.
- W2373673375 citedByCount "0" @default.
- W2373673375 crossrefType "journal-article" @default.
- W2373673375 hasAuthorship W2373673375A5027168462 @default.
- W2373673375 hasConcept C185592680 @default.
- W2373673375 hasConcept C202751555 @default.
- W2373673375 hasConcept C2776962512 @default.
- W2373673375 hasConcept C2777752497 @default.
- W2373673375 hasConcept C2780206985 @default.
- W2373673375 hasConcept C2780783641 @default.
- W2373673375 hasConcept C501593827 @default.
- W2373673375 hasConcept C55493867 @default.
- W2373673375 hasConcept C71924100 @default.
- W2373673375 hasConcept C98274493 @default.
- W2373673375 hasConceptScore W2373673375C185592680 @default.
- W2373673375 hasConceptScore W2373673375C202751555 @default.
- W2373673375 hasConceptScore W2373673375C2776962512 @default.
- W2373673375 hasConceptScore W2373673375C2777752497 @default.
- W2373673375 hasConceptScore W2373673375C2780206985 @default.
- W2373673375 hasConceptScore W2373673375C2780783641 @default.
- W2373673375 hasConceptScore W2373673375C501593827 @default.
- W2373673375 hasConceptScore W2373673375C55493867 @default.
- W2373673375 hasConceptScore W2373673375C71924100 @default.
- W2373673375 hasConceptScore W2373673375C98274493 @default.
- W2373673375 hasLocation W23736733751 @default.
- W2373673375 hasOpenAccess W2373673375 @default.
- W2373673375 hasPrimaryLocation W23736733751 @default.
- W2373673375 hasRelatedWork W1556000923 @default.
- W2373673375 hasRelatedWork W161686747 @default.
- W2373673375 hasRelatedWork W1949076913 @default.
- W2373673375 hasRelatedWork W2019440591 @default.
- W2373673375 hasRelatedWork W2039425990 @default.
- W2373673375 hasRelatedWork W2039718645 @default.
- W2373673375 hasRelatedWork W2053388547 @default.
- W2373673375 hasRelatedWork W2092634814 @default.
- W2373673375 hasRelatedWork W2168358561 @default.
- W2373673375 hasRelatedWork W2377982083 @default.
- W2373673375 hasRelatedWork W2396494332 @default.
- W2373673375 hasRelatedWork W2397981011 @default.
- W2373673375 hasRelatedWork W2404234415 @default.
- W2373673375 hasRelatedWork W2533493352 @default.
- W2373673375 hasRelatedWork W2951222069 @default.
- W2373673375 hasRelatedWork W2954309692 @default.
- W2373673375 hasRelatedWork W3021550563 @default.
- W2373673375 hasRelatedWork W3160932352 @default.
- W2373673375 hasRelatedWork W2778385550 @default.
- W2373673375 hasRelatedWork W3018729451 @default.
- W2373673375 isParatext "false" @default.
- W2373673375 isRetracted "false" @default.
- W2373673375 magId "2373673375" @default.
- W2373673375 workType "article" @default.