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- W2373695706 abstract "Aim:To study the effects of FTY720 on ischemia-reperfusion injury of rat cardiac allografts.Methods:The model of rat heterotopic heart transplantation was established with Cuff technique.The recipient rats of the FTY720-treated group(n=6) was administered with FTY720 orally at a dosage of 3 mg/kg for 3 days before grafting operation,and the control group was administered with normal saline at a dosage of 3 mL/kg.All recipients were sacrificed and the donor hearts were removed at 8 hours after transplantation.The ultrastructure of the graft tissues was observed under electron microscope.Apoptosis index(AI) in grafts was determined by TUNEL.Grafts' SOD activity,MDA content,and MPO activity were measured.Results:At 8 hours after transplantation in FTY720-treated group,there were less cellular swelling,less inflammatory cell infiltration and less mitochondrial oedema of cadiocyte.Compared with control group,the cell apoptosis in FTY720-treated group decreased [AI:(9.20±1.12) vs.(16.10±1.65),t=8.475,P0.001)],SOD activity [(51.03±5.54) mmol/g vs.(28.39±2.38) mmol/g] was higher,and MDA content[(10.90±1.93) U/g vs.(16.27±1.36) U/g] and MPO activity [(4.38±1.43) mU/g vs.(9.26±1.41) mU/g] were lower(t=9.197,5.571,and 5.592,P0.001).Conclusion:FTY720 could ameliorate the myocardial ischemia-reperfusion injury in rat heart transplantation." @default.
- W2373695706 created "2016-06-24" @default.
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- W2373695706 date "2010-01-01" @default.
- W2373695706 modified "2023-09-25" @default.
- W2373695706 title "Effects of FTY720 on ischemia-reperfusion injury of rat cardiac allografts" @default.
- W2373695706 hasPublicationYear "2010" @default.
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