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- W2373699698 abstract "Objective:In the light of the contention of high dose glucocorticoids on cerebral protection at prsesnt,this study will testify if high-dose glucocorticoids has protective action on brain,and provide a theoretical basis for clinical administration of cerebral protection.Methods:The study examined the changes of excitatory amino acids(EAAs)-Glutamic acid(Glu)?Aspartic acid(Asp) and monoamine neurotransmitters-Dopamine(DA).5-hydroxytryp tamine(5-HT) after administration of high-dose glucocorticoids by setting up standard Ventricular Fibrllation-Cardiac arrest(VF-CA) model in dogs,and observe the corres ponding changes in cerebral histologic respect,so as to evaluate the value of the administration of high-dose glucocorticoids on cerebral resuscitation.Results:High-dose glucocorticoids can reduce the release of Glu and Asp from brain,which demonstrate the concentration of Glu and ASP in peripheral blood reducing remarkably,moreover,the content of DA and 5-HT in cerbral cortex is reduced too in glucocorticoids group;in the meantime,the degree of brain edema and the damage of celluar organ are diminished by examination in microscope and electronic microscope.Conclusion:High-dose glucocorticoids has an effetive action on cerebral protection." @default.
- W2373699698 created "2016-06-24" @default.
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- W2373699698 date "2003-01-01" @default.
- W2373699698 modified "2023-09-25" @default.
- W2373699698 title "Effect of High-does Glucocorticoids on Brain Resuscitation After Cardiopulmonary Resuscitation" @default.
- W2373699698 hasPublicationYear "2003" @default.
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