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- W2373722668 abstract "It was recently found that small RNAs(sRNAs)in prokaryotes are ranged in size from 50 to 250 nucleotides,are generally untranslated,and play key roles in post-transcriptional regulation.They were first discovered in Escherichia coli,and almost 140 sRNAs have been revealed by computational prediction and experimental approaches.It has made clear that the functional mechanism of sRNAs include inhibition or activation of translation by base pairing with the translation initiation sites or the leader segments on their target mRNAs.In addition,a few of them could mimic the secondary structures of other nucleic acids to derepress the translational inhibition by removing mRNA binding protein.Besides,some sRNAs could also mimic the DNA corresponding to an open promoter to sequester the RNA polymerase from mRNAs to block transcription." @default.
- W2373722668 created "2016-06-24" @default.
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- W2373722668 date "2008-01-01" @default.
- W2373722668 modified "2023-09-23" @default.
- W2373722668 title "The advances of sRNA research in prokaryotes" @default.
- W2373722668 hasPublicationYear "2008" @default.
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